Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1158455..1159073 Replicon chromosome
Accession NZ_CP098183
Organism Escherichia coli strain Z0117EC0133

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NBY27_RS05400 Protein ID WP_001291435.1
Coordinates 1158455..1158673 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NBY27_RS05405 Protein ID WP_000344800.1
Coordinates 1158699..1159073 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY27_RS05365 (1153744) 1153744..1154316 + 573 WP_000779831.1 YbaY family lipoprotein -
NBY27_RS05370 (1154347) 1154347..1154658 - 312 WP_000409911.1 MGMT family protein -
NBY27_RS05380 (1155037) 1155037..1155390 + 354 WP_000878140.1 DUF1428 domain-containing protein -
NBY27_RS05385 (1155432) 1155432..1156982 - 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NBY27_RS05390 (1157146) 1157146..1157616 - 471 WP_000136192.1 YlaC family protein -
NBY27_RS05395 (1157732) 1157732..1158283 - 552 WP_000102564.1 maltose O-acetyltransferase -
NBY27_RS05400 (1158455) 1158455..1158673 - 219 WP_001291435.1 HHA domain-containing protein Toxin
NBY27_RS05405 (1158699) 1158699..1159073 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NBY27_RS05410 (1159619) 1159619..1162768 - 3150 WP_001132469.1 efflux RND transporter permease AcrB -
NBY27_RS05415 (1162791) 1162791..1163984 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T246860 WP_001291435.1 NZ_CP098183:c1158673-1158455 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT246860 WP_000344800.1 NZ_CP098183:c1159073-1158699 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References