Detailed information of TA system TA024686

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 904312..904765
• Replicon: chromosome
• Accession: NC_013971
• Organism: Erwinia amylovora ATCC 49946

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: EAM_RS03910
• Protein ID: WP_013035888.1
• Coordinates: 904529..904765 (+)
• Length: 79 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: D4HZA2
• Locus tag: EAM_RS03905
• Protein ID: WP_004159527.1
• Coordinates: 904312..904539 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EAM_RS03895 (EAM_0800)	903236..903640	+	405	WP_013035886.1	hypothetical protein	-
EAM_RS03900 (EAM_0801)	903704..903991	-	288	WP_004159528.1	SymE family type I addiction module toxin	-
EAM_RS03905 (EAM_0802)	904312..904539	+	228	WP_004159527.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
EAM_RS03910 (EAM_0803)	904529..904765	+	237	WP_013035888.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EAM_RS03915	904752..904970	-	219	WP_004159522.1	hypothetical protein	-
EAM_RS03920 (EAM_0805)	905298..907514	+	2217	Protein_756	ferrichrome porin FhuA	-
EAM_RS03925 (EAM_0806)	907563..908357	+	795	WP_004159512.1	Fe3+-hydroxamate ABC transporter ATP-binding protein FhuC	-
EAM_RS03930 (EAM_0807)	908372..909250	+	879	WP_004159509.1	Fe(3+)-hydroxamate ABC transporter substrate-binding protein FhuD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-78)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-75)

Sequences

Toxin

Protein

• Length: 79 a.a.
• Molecular weight: 9135.79 Da
• Isoelectric Point: 9.0876

>T24686 WP_013035888.1 NC_013971:904529-904765 [Erwinia amylovora ATCC 49946]
ISYELLFDPWALKEWKKLGATVREQFKKKLAEVLVNLQVESARLRDHPDCCKIKLKSSGYRLVYQVQDEQLVMLVISV

Nucleotide

• Length: 237 bp

>T24686 NC_013971:904529-904765 [Erwinia amylovora ATCC 49946]
ATAAGCTATGAACTGCTCTTCGATCCCTGGGCCTTAAAAGAGTGGAAAAAACTGGGCGCAACGGTTCGGGAACAGTTCAA
AAAGAAACTGGCGGAAGTGCTGGTAAACCTGCAGGTGGAATCAGCCAGGCTGAGAGATCACCCGGACTGCTGCAAAATAA
AGCTGAAATCATCGGGTTATCGTCTGGTATATCAGGTTCAGGATGAACAGCTGGTAATGTTGGTTATAAGCGTTTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8435.90 Da
• Isoelectric Point: 7.9766

>AT24686 WP_004159527.1 NC_013971:904312-904539 [Erwinia amylovora ATCC 49946]
VRLDDKLKSKACAVLDELDVSPTEAVRLLFQYIAENERLPLKALTVSDEKDALLKTVRERLASLQKGIKVTLDKL

Nucleotide

• Length: 228 bp

>AT24686 NC_013971:904312-904539 [Erwinia amylovora ATCC 49946]
GTGCGGCTGGATGACAAACTGAAAAGCAAAGCCTGTGCAGTTCTGGATGAACTGGATGTATCGCCAACGGAGGCGGTCCG
GCTGTTGTTCCAGTATATAGCGGAAAATGAGCGCCTACCGCTGAAAGCGCTGACGGTAAGTGATGAAAAAGACGCGCTGC
TGAAAACGGTTCGCGAAAGGCTGGCATCGCTACAGAAGGGAATAAAGGTAACGCTGGATAAGCTATGA

Structures

Antitoxin

• AlphaFold DB: A0A831A410