Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 524334..524929 Replicon chromosome
Accession NZ_CP098183
Organism Escherichia coli strain Z0117EC0133

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag NBY27_RS02455 Protein ID WP_000239579.1
Coordinates 524579..524929 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag NBY27_RS02450 Protein ID WP_001223208.1
Coordinates 524334..524585 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY27_RS02440 (519998) 519998..523777 + 3780 WP_000060921.1 autotransporter assembly complex protein TamB -
NBY27_RS02445 (523780) 523780..524121 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
NBY27_RS02450 (524334) 524334..524585 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
NBY27_RS02455 (524579) 524579..524929 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
NBY27_RS02460 (525009) 525009..525539 - 531 WP_000055072.1 inorganic diphosphatase -
NBY27_RS02465 (525849) 525849..526805 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
NBY27_RS02470 (527115) 527115..528617 + 1503 WP_250790864.1 sugar ABC transporter ATP-binding protein -
NBY27_RS02475 (528631) 528631..529653 + 1023 WP_001296689.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T246857 WP_000239579.1 NZ_CP098183:524579-524929 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT246857 WP_001223208.1 NZ_CP098183:524334-524585 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References