Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 88679..89226 Replicon plasmid pZ0117EC0148-2
Accession NZ_CP098180
Organism Escherichia coli strain Z0117EC0148

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag NBY28_RS24665 Protein ID WP_246777396.1
Coordinates 88679..88957 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag NBY28_RS24670 Protein ID WP_063848275.1
Coordinates 88957..89226 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY28_RS24640 (84490) 84490..85452 - 963 Protein_97 IS110 family transposase -
NBY28_RS24645 (85763) 85763..85951 + 189 WP_000957857.1 hypothetical protein -
NBY28_RS24650 (85961) 85961..87160 + 1200 WP_000948429.1 IS91 family transposase -
NBY28_RS24655 (87335) 87335..87881 + 547 Protein_100 transposase -
NBY28_RS24660 (88070) 88070..88633 - 564 Protein_101 3'-5' exonuclease -
NBY28_RS24665 (88679) 88679..88957 - 279 WP_246777396.1 type II toxin-antitoxin system toxin YacB Toxin
NBY28_RS24670 (88957) 88957..89226 - 270 WP_063848275.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
NBY28_RS24675 (89281) 89281..89439 - 159 WP_001470858.1 hypothetical protein -
NBY28_RS24680 (90133) 90133..91164 - 1032 WP_250844259.1 plasmid replication initiator RepA -
NBY28_RS24685 (92170) 92170..92400 + 231 WP_228772074.1 ash family protein -
NBY28_RS24690 (92318) 92318..92605 + 288 WP_000074849.1 conjugal transfer protein TraA -
NBY28_RS24695 (93047) 93047..93580 + 534 WP_001372168.1 transcription termination/antitermination NusG family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaCTX-M-14 / qnrS1 - 1..100768 100768


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10743.40 Da        Isoelectric Point: 9.7617

>T246852 WP_246777396.1 NZ_CP098180:c88957-88679 [Escherichia coli]
MEIFWTILASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVKGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10210.55 Da        Isoelectric Point: 8.8735

>AT246852 WP_063848275.1 NZ_CP098180:c89226-88957 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLGRGDVLPHDMVESSAAAWRD
EMSRKVTGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References