Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 4497176..4497807 Replicon chromosome
Accession NZ_CP098178
Organism Escherichia coli strain Z0117EC0148

Toxin (Protein)


Gene name hicA Uniprot ID F4NNK6
Locus tag NBY28_RS22025 Protein ID WP_001259388.1
Coordinates 4497532..4497807 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag NBY28_RS22020 Protein ID WP_000593555.1
Coordinates 4497176..4497535 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY28_RS21995 (4493308) 4493308..4494252 + 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -
NBY28_RS22000 (4494249) 4494249..4495082 + 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
NBY28_RS22005 (4495082) 4495082..4495846 + 765 WP_001136236.1 nickel import ATP-binding protein NikD -
NBY28_RS22010 (4495843) 4495843..4496649 + 807 WP_124783472.1 nickel import ATP-binding protein NikE -
NBY28_RS22015 (4496655) 4496655..4497056 + 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
NBY28_RS22020 (4497176) 4497176..4497535 - 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NBY28_RS22025 (4497532) 4497532..4497807 - 276 WP_001259388.1 type II toxin-antitoxin system HicA family toxin Toxin
NBY28_RS22030 (4497880) 4497880..4499004 - 1125 WP_001314210.1 ABC transporter permease -
NBY28_RS22035 (4499004) 4499004..4501739 - 2736 WP_000149125.1 ribosome-associated ATPase/putative transporter RbbA -
NBY28_RS22040 (4501736) 4501736..4502803 - 1068 WP_000361485.1 HlyD family secretion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10151.89 Da        Isoelectric Point: 10.7076

>T246839 WP_001259388.1 NZ_CP098178:c4497807-4497532 [Escherichia coli]
MRTKVQALRKKQKNTLDQIVKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT246839 WP_000593555.1 NZ_CP098178:c4497535-4497176 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A0FFA2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References