Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3918319..3918973 Replicon chromosome
Accession NZ_CP098178
Organism Escherichia coli strain Z0117EC0148

Toxin (Protein)


Gene name cptA Uniprot ID F4NJ21
Locus tag NBY28_RS19100 Protein ID WP_000244772.1
Coordinates 3918319..3918726 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag NBY28_RS19105 Protein ID WP_000354046.1
Coordinates 3918707..3918973 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY28_RS19080 (3914276) 3914276..3916009 - 1734 WP_000813210.1 single-stranded-DNA-specific exonuclease RecJ -
NBY28_RS19085 (3916015) 3916015..3916725 - 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NBY28_RS19090 (3916750) 3916750..3917646 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
NBY28_RS19095 (3917758) 3917758..3918279 + 522 WP_001055874.1 flavodoxin FldB -
NBY28_RS19100 (3918319) 3918319..3918726 - 408 WP_000244772.1 protein YgfX Toxin
NBY28_RS19105 (3918707) 3918707..3918973 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
NBY28_RS19110 (3919216) 3919216..3920196 + 981 WP_001472148.1 tRNA-modifying protein YgfZ -
NBY28_RS19115 (3920273) 3920273..3920932 - 660 WP_000250274.1 hemolysin III family protein -
NBY28_RS19120 (3921096) 3921096..3921407 - 312 WP_001182944.1 N(4)-acetylcytidine aminohydrolase -
NBY28_RS19125 (3921452) 3921452..3922885 + 1434 WP_001307385.1 6-phospho-beta-glucosidase BglA -
NBY28_RS19130 (3922942) 3922942..3923685 - 744 WP_000951964.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16048.02 Da        Isoelectric Point: 11.2511

>T246837 WP_000244772.1 NZ_CP098178:c3918726-3918319 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT246837 WP_000354046.1 NZ_CP098178:c3918973-3918707 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XYB4

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References