Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3485869..3486494 Replicon chromosome
Accession NZ_CP098178
Organism Escherichia coli strain Z0117EC0148

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NBY28_RS17055 Protein ID WP_000911330.1
Coordinates 3485869..3486267 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag NBY28_RS17060 Protein ID WP_000450524.1
Coordinates 3486267..3486494 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY28_RS17035 (3481747) 3481747..3481947 + 201 WP_000383836.1 YpfN family protein -
NBY28_RS17040 (3482057) 3482057..3482755 - 699 WP_000679823.1 esterase -
NBY28_RS17045 (3482829) 3482829..3484844 - 2016 WP_000829294.1 tRNA cytosine(34) acetyltransferase TmcA -
NBY28_RS17050 (3484859) 3484859..3485722 - 864 WP_001267498.1 neutral zinc metallopeptidase -
NBY28_RS17055 (3485869) 3485869..3486267 - 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
NBY28_RS17060 (3486267) 3486267..3486494 - 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
NBY28_RS17065 (3486648) 3486648..3487361 - 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
NBY28_RS17070 (3487574) 3487574..3488608 - 1035 WP_001330579.1 outer membrane protein assembly factor BamC -
NBY28_RS17075 (3488625) 3488625..3489503 - 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
NBY28_RS17080 (3489649) 3489649..3490221 + 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
NBY28_RS17085 (3490221) 3490221..3490691 + 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T246835 WP_000911330.1 NZ_CP098178:c3486267-3485869 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT246835 WP_000450524.1 NZ_CP098178:c3486494-3486267 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References