Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2448437..2449533 Replicon chromosome
Accession NZ_CP098178
Organism Escherichia coli strain Z0117EC0148

Toxin (Protein)


Gene name hipA Uniprot ID A0A8S7TJ53
Locus tag NBY28_RS11975 Protein ID WP_063112742.1
Coordinates 2448437..2449267 (-) Length 277 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NBY28_RS11980 Protein ID WP_001296726.1
Coordinates 2449267..2449533 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY28_RS11960 (2445852) 2445852..2446562 - 711 WP_001195166.1 fimbria/pilus periplasmic chaperone -
NBY28_RS11965 (2446922) 2446922..2447485 - 564 WP_001296758.1 type 1 fimbrial major subunit FimA -
NBY28_RS11970 (2447917) 2447917..2448125 - 209 Protein_2332 AraC family transcriptional regulator -
NBY28_RS11975 (2448437) 2448437..2449267 - 831 WP_063112742.1 HipA N-terminal domain-containing protein Toxin
NBY28_RS11980 (2449267) 2449267..2449533 - 267 WP_001296726.1 type II toxin-antitoxin system antitoxin HipB Antitoxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimA 2433938..2449714 15776


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(115-237)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 277 a.a.        Molecular weight: 31181.99 Da        Isoelectric Point: 10.0235

>T246829 WP_063112742.1 NZ_CP098178:c2449267-2448437 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEKLTEARLEDRYDFMKFQVFQWLIGATDGHAKNFSVFIQAGGS
YRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIPAALD
NVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGSK

Download         Length: 831 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10047.39 Da        Isoelectric Point: 4.9632

>AT246829 WP_001296726.1 NZ_CP098178:c2449533-2449267 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References