Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1253250..1253868 Replicon chromosome
Accession NZ_CP098178
Organism Escherichia coli strain Z0117EC0148

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NBY28_RS06050 Protein ID WP_001291435.1
Coordinates 1253250..1253468 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NBY28_RS06055 Protein ID WP_000344800.1
Coordinates 1253494..1253868 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY28_RS06015 (1248539) 1248539..1249111 + 573 WP_000779826.1 YbaY family lipoprotein -
NBY28_RS06020 (1249142) 1249142..1249453 - 312 WP_000409911.1 MGMT family protein -
NBY28_RS06030 (1249832) 1249832..1250185 + 354 WP_000878141.1 DUF1428 family protein -
NBY28_RS06035 (1250227) 1250227..1251777 - 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NBY28_RS06040 (1251941) 1251941..1252411 - 471 WP_000136192.1 YlaC family protein -
NBY28_RS06045 (1252527) 1252527..1253078 - 552 WP_000102564.1 maltose O-acetyltransferase -
NBY28_RS06050 (1253250) 1253250..1253468 - 219 WP_001291435.1 HHA domain-containing protein Toxin
NBY28_RS06055 (1253494) 1253494..1253868 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NBY28_RS06060 (1254414) 1254414..1257563 - 3150 WP_001132469.1 efflux RND transporter permease AcrB -
NBY28_RS06065 (1257586) 1257586..1258779 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T246825 WP_001291435.1 NZ_CP098178:c1253468-1253250 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT246825 WP_000344800.1 NZ_CP098178:c1253868-1253494 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References