Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4381852..4382509 Replicon chromosome
Accession NZ_CP098175
Organism Klebsiella pneumoniae strain Z0117KP0001

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag NBY29_RS21365 Protein ID WP_002916310.1
Coordinates 4381852..4382262 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag NBY29_RS21370 Protein ID WP_002916312.1
Coordinates 4382243..4382509 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY29_RS21345 (4377852) 4377852..4379585 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
NBY29_RS21350 (4379591) 4379591..4380304 - 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NBY29_RS21355 (4380327) 4380327..4381223 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
NBY29_RS21360 (4381324) 4381324..4381845 + 522 WP_004144730.1 flavodoxin FldB -
NBY29_RS21365 (4381852) 4381852..4382262 - 411 WP_002916310.1 protein YgfX Toxin
NBY29_RS21370 (4382243) 4382243..4382509 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
NBY29_RS21375 (4382755) 4382755..4383738 + 984 WP_004185555.1 tRNA-modifying protein YgfZ -
NBY29_RS21380 (4383889) 4383889..4384548 - 660 WP_002916317.1 hemolysin III family protein -
NBY29_RS21385 (4384712) 4384712..4385023 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
NBY29_RS21390 (4385073) 4385073..4385801 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
NBY29_RS21395 (4385920) 4385920..4387353 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T246817 WP_002916310.1 NZ_CP098175:c4382262-4381852 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT246817 WP_002916312.1 NZ_CP098175:c4382509-4382243 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References