Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 612987..613797 Replicon chromosome
Accession NZ_CP098175
Organism Klebsiella pneumoniae strain Z0117KP0001

Toxin (Protein)


Gene name KacT Uniprot ID A0A060VJ83
Locus tag NBY29_RS02875 Protein ID WP_004178461.1
Coordinates 613264..613797 (+) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag NBY29_RS02870 Protein ID WP_002887278.1
Coordinates 612987..613253 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY29_RS02850 (608859) 608859..609203 - 345 WP_004214146.1 cation efflux system protein CusF -
NBY29_RS02855 (609221) 609221..610606 - 1386 WP_023302432.1 efflux transporter outer membrane subunit -
NBY29_RS02860 (610778) 610778..611461 + 684 WP_023302433.1 copper response regulator transcription factor CusR -
NBY29_RS02865 (611451) 611451..612884 + 1434 WP_029498528.1 Cu(+)/Ag(+) sensor histidine kinase -
NBY29_RS02870 (612987) 612987..613253 + 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
NBY29_RS02875 (613264) 613264..613797 + 534 WP_004178461.1 type II toxin-antitoxin system toxin KacT Toxin
NBY29_RS02880 (613845) 613845..614966 - 1122 WP_012737335.1 cupin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19810.65 Da        Isoelectric Point: 5.2614

>T246810 WP_004178461.1 NZ_CP098175:613264-613797 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT246810 WP_002887278.1 NZ_CP098175:612987-613253 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060VJ83

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References