Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 522718..523234 Replicon chromosome
Accession NZ_CP098175
Organism Klebsiella pneumoniae strain Z0117KP0001

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag NBY29_RS02460 Protein ID WP_002886902.1
Coordinates 522950..523234 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag NBY29_RS02455 Protein ID WP_002886901.1
Coordinates 522718..522960 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY29_RS02440 (518746) 518746..519486 + 741 WP_002886899.1 KDGP aldolase family protein -
NBY29_RS02445 (519553) 519553..520707 + 1155 WP_085808042.1 lactonase family protein -
NBY29_RS02450 (520730) 520730..522640 + 1911 WP_009486549.1 PRD domain-containing protein -
NBY29_RS02455 (522718) 522718..522960 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NBY29_RS02460 (522950) 522950..523234 + 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NBY29_RS02465 (523238) 523238..523702 - 465 WP_023302390.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NBY29_RS02470 (524011) 524011..526149 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
NBY29_RS02475 (526506) 526506..527249 - 744 WP_021441079.1 MurR/RpiR family transcriptional regulator -
NBY29_RS02480 (527252) 527252..527425 - 174 WP_032410138.1 hypothetical protein -
NBY29_RS02485 (527555) 527555..527818 + 264 WP_014908078.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T246809 WP_002886902.1 NZ_CP098175:522950-523234 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT246809 WP_002886901.1 NZ_CP098175:522718-522960 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References