Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/ElaA-DUF1778
Location 160208..160959 Replicon plasmid pZ0117KP0003-1
Accession NZ_CP098170
Organism Klebsiella pneumoniae strain Z0117KP0003

Toxin (Protein)


Gene name ataT Uniprot ID H6U1U8
Locus tag NBY30_RS24810 Protein ID WP_014386536.1
Coordinates 160208..160690 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A071LPN3
Locus tag NBY30_RS24815 Protein ID WP_004902250.1
Coordinates 160681..160959 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY30_RS24790 (NBY30_24780) 156607..157254 - 648 WP_014386537.1 EcsC family protein -
NBY30_RS24795 (NBY30_24785) 157281..158036 - 756 WP_004902235.1 DUF2971 domain-containing protein -
NBY30_RS24800 (NBY30_24790) 158137..158529 - 393 WP_032442757.1 hypothetical protein -
NBY30_RS24805 (NBY30_24795) 158634..159173 - 540 WP_004902239.1 hypothetical protein -
NBY30_RS24810 (NBY30_24800) 160208..160690 - 483 WP_014386536.1 GNAT family N-acetyltransferase Toxin
NBY30_RS24815 (NBY30_24805) 160681..160959 - 279 WP_004902250.1 DUF1778 domain-containing protein Antitoxin
NBY30_RS24820 (NBY30_24810) 161078..161290 - 213 WP_004902255.1 hypothetical protein -
NBY30_RS24825 (NBY30_24815) 161398..161739 - 342 WP_004902257.1 hypothetical protein -
NBY30_RS24830 (NBY30_24820) 162569..163027 - 459 WP_014386535.1 hypothetical protein -
NBY30_RS24835 (NBY30_24825) 163680..164135 - 456 WP_250833687.1 Hg(II)-responsive transcriptional regulator -
NBY30_RS24840 (NBY30_24830) 164207..164572 + 366 WP_001294656.1 mercuric ion transporter MerT -
NBY30_RS24845 (NBY30_24835) 164588..164863 + 276 WP_000732275.1 mercury resistance system periplasmic binding protein MerP -
NBY30_RS24850 (NBY30_24840) 164891..165316 + 426 WP_000522996.1 organomercurial transporter MerC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid tet(B) / aph(3')-Ia - 1..253995 253995


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(10-86)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17662.45 Da        Isoelectric Point: 8.9130

>T246806 WP_014386536.1 NZ_CP098170:c160690-160208 [Klebsiella pneumoniae]
MGMRAPESLTAEHNIAEFCCQEPALNEWLKKKALRNHSTGISRVYVVCAENTNRVIGYYCLSSGSVHRNTVPGAYRRNAP
DVIPVIVLGRLAIDQAWAGNGLGAALLKDAIYRTQNIAFQVGVRALAVHALNEEVKCFYTRFGFEPSIVNTLTLLFPIKV

Download         Length: 483 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10704.23 Da        Isoelectric Point: 4.5271

>AT246806 WP_004902250.1 NZ_CP098170:c160959-160681 [Klebsiella pneumoniae]
MKPDVREAPINIRAKTSQRDLIDMAASLVSKSRTDFMLEVACREAQDILLDQRLFLLNDNQFEAFIEELDAPITPERQAR
IDNLMNRKSPWE

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MBI1

Antitoxin

Source ID Structure
AlphaFold DB A0A071LPN3

References