Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-TIGR02293 |
| Location | 78947..79857 | Replicon | plasmid pZ0117KP0003-1 |
| Accession | NZ_CP098170 | ||
| Organism | Klebsiella pneumoniae strain Z0117KP0003 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A663AYG0 |
| Locus tag | NBY30_RS24415 | Protein ID | WP_004026354.1 |
| Coordinates | 79387..79857 (+) | Length | 157 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A2J4RLY9 |
| Locus tag | NBY30_RS24410 | Protein ID | WP_004181895.1 |
| Coordinates | 78947..79390 (+) | Length | 148 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NBY30_RS24395 (NBY30_24385) | 75580..77067 | + | 1488 | WP_004178082.1 | group II intron reverse transcriptase/maturase | - |
| NBY30_RS24400 (NBY30_24390) | 77153..77575 | + | 423 | WP_004181893.1 | translesion error-prone DNA polymerase V autoproteolytic subunit | - |
| NBY30_RS24405 (NBY30_24395) | 77575..78846 | + | 1272 | WP_004181894.1 | translesion error-prone DNA polymerase V subunit UmuC | - |
| NBY30_RS24410 (NBY30_24400) | 78947..79390 | + | 444 | WP_004181895.1 | DUF2384 domain-containing protein | Antitoxin |
| NBY30_RS24415 (NBY30_24405) | 79387..79857 | + | 471 | WP_004026354.1 | RES family NAD+ phosphorylase | Toxin |
| NBY30_RS24420 (NBY30_24410) | 79967..80227 | - | 261 | WP_004026352.1 | hypothetical protein | - |
| NBY30_RS24425 (NBY30_24415) | 80951..81109 | + | 159 | WP_004181898.1 | type I toxin-antitoxin system Hok family toxin | - |
| NBY30_RS24430 (NBY30_24420) | 81712..82686 | + | 975 | WP_014386572.1 | hypothetical protein | - |
| NBY30_RS24435 (NBY30_24425) | 82884..83261 | - | 378 | WP_004181901.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | tet(B) / aph(3')-Ia | - | 1..253995 | 253995 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17515.79 Da Isoelectric Point: 4.6155
>T246805 WP_004026354.1 NZ_CP098170:79387-79857 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
Antitoxin
Download Length: 148 a.a. Molecular weight: 16536.87 Da Isoelectric Point: 10.3013
>AT246805 WP_004181895.1 NZ_CP098170:78947-79390 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A663AYG0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2J4RLY9 |