Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4642118..4643706 Replicon chromosome
Accession NZ_CP098169
Organism Klebsiella pneumoniae strain Z0117KP0003

Toxin (Protein)


Gene name hipA Uniprot ID W8UI36
Locus tag NBY30_RS22675 Protein ID WP_002904792.1
Coordinates 4642118..4643440 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag NBY30_RS22680 Protein ID WP_002904790.1
Coordinates 4643440..4643706 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY30_RS22660 (4637174) 4637174..4639675 + 2502 WP_032433099.1 fimbria/pilus outer membrane usher protein -
NBY30_RS22665 (4639663) 4639663..4640667 + 1005 WP_032433097.1 fimbrial protein -
NBY30_RS22670 (4640809) 4640809..4642101 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
NBY30_RS22675 (4642118) 4642118..4643440 - 1323 WP_002904792.1 type II toxin-antitoxin system HipA family toxin Toxin
NBY30_RS22680 (4643440) 4643440..4643706 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NBY30_RS22685 (4644092) 4644092..4644418 - 327 WP_002904788.1 hydroxyisourate hydrolase -
NBY30_RS22690 (4644415) 4644415..4644915 - 501 WP_032433095.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
NBY30_RS22695 (4644893) 4644893..4646272 - 1380 WP_032433093.1 nucleobase:cation symporter-2 family protein -
NBY30_RS22700 (4646618) 4646618..4647772 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
NBY30_RS22705 (4647753) 4647753..4648676 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T246804 WP_002904792.1 NZ_CP098169:c4643440-4642118 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT246804 WP_002904790.1 NZ_CP098169:c4643706-4643440 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CEC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References