Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 3429335..3429978 Replicon chromosome
Accession NZ_CP098169
Organism Klebsiella pneumoniae strain Z0117KP0003

Toxin (Protein)


Gene name vagD Uniprot ID A0A4S8C081
Locus tag NBY30_RS16590 Protein ID WP_032433387.1
Coordinates 3429562..3429978 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q84A07
Locus tag NBY30_RS16585 Protein ID WP_001261276.1
Coordinates 3429335..3429565 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY30_RS16570 (3424357) 3424357..3425444 + 1088 Protein_3216 transcriptional repressor PifC -
NBY30_RS16575 (3425447) 3425447..3427687 + 2241 WP_045326788.1 P-loop NTPase fold protein -
NBY30_RS16580 (3428215) 3428215..3429030 - 816 WP_032433388.1 hypothetical protein -
NBY30_RS16585 (3429335) 3429335..3429565 + 231 WP_001261276.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NBY30_RS16590 (3429562) 3429562..3429978 + 417 WP_032433387.1 type II toxin-antitoxin system VapC family toxin Toxin
NBY30_RS16595 (3430134) 3430134..3431114 + 981 WP_032433385.1 hypothetical protein -
NBY30_RS16600 (3431309) 3431309..3432880 - 1572 WP_250833665.1 AAA family ATPase -
NBY30_RS16605 (3433199) 3433199..3433447 + 249 WP_032433382.1 hypothetical protein -
NBY30_RS16610 (3433506) 3433506..3434024 + 519 WP_045326794.1 hypothetical protein -
NBY30_RS16615 (3434055) 3434055..3434282 + 228 Protein_3225 DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3416249..3461326 45077
- flank IS/Tn - - 3434305..3435513 1208


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14974.43 Da        Isoelectric Point: 7.8921

>T246798 WP_032433387.1 NZ_CP098169:3429562-3429978 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALHLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFARVPGLTLEDWVI

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8721.74 Da        Isoelectric Point: 4.3533

>AT246798 WP_001261276.1 NZ_CP098169:3429335-3429565 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S8C081

Antitoxin

Source ID Structure
AlphaFold DB A0A387K023

References