Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2797691..2798348 Replicon chromosome
Accession NZ_CP098169
Organism Klebsiella pneumoniae strain Z0117KP0003

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag NBY30_RS13515 Protein ID WP_002916310.1
Coordinates 2797938..2798348 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag NBY30_RS13510 Protein ID WP_002916312.1
Coordinates 2797691..2797957 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY30_RS13485 (2792847) 2792847..2794280 - 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -
NBY30_RS13490 (2794399) 2794399..2795127 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
NBY30_RS13495 (2795177) 2795177..2795488 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
NBY30_RS13500 (2795652) 2795652..2796311 + 660 WP_002916317.1 hemolysin III family protein -
NBY30_RS13505 (2796462) 2796462..2797445 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
NBY30_RS13510 (2797691) 2797691..2797957 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
NBY30_RS13515 (2797938) 2797938..2798348 + 411 WP_002916310.1 protein YgfX Toxin
NBY30_RS13520 (2798355) 2798355..2798876 - 522 WP_004144730.1 flavodoxin FldB -
NBY30_RS13525 (2798977) 2798977..2799873 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
NBY30_RS13530 (2799896) 2799896..2800609 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NBY30_RS13535 (2800615) 2800615..2802348 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T246797 WP_002916310.1 NZ_CP098169:2797938-2798348 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT246797 WP_002916312.1 NZ_CP098169:2797691-2797957 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References