Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2667593..2668398 Replicon chromosome
Accession NZ_CP098169
Organism Klebsiella pneumoniae strain Z0117KP0003

Toxin (Protein)


Gene name yeeV Uniprot ID A0A443UJW7
Locus tag NBY30_RS12840 Protein ID WP_065523303.1
Coordinates 2667593..2667982 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A443UJP3
Locus tag NBY30_RS12845 Protein ID WP_049594224.1
Coordinates 2668039..2668398 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY30_RS12825 (2663385) 2663385..2664533 - 1149 WP_032433524.1 PLP-dependent aspartate aminotransferase family protein -
NBY30_RS12830 (2664544) 2664544..2665920 - 1377 WP_016947440.1 cystathionine beta-synthase -
NBY30_RS12835 (2666676) 2666676..2667520 - 845 Protein_2490 DUF4942 domain-containing protein -
NBY30_RS12840 (2667593) 2667593..2667982 - 390 WP_065523303.1 TA system toxin CbtA family protein Toxin
NBY30_RS12845 (2668039) 2668039..2668398 - 360 WP_049594224.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
NBY30_RS12850 (2668423) 2668423..2668644 - 222 WP_047724679.1 DUF987 domain-containing protein -
NBY30_RS12855 (2668658) 2668658..2669137 - 480 WP_094963398.1 DNA repair protein RadC -
NBY30_RS12860 (2669149) 2669149..2669592 - 444 WP_049594225.1 antirestriction protein -
NBY30_RS12865 (2669672) 2669672..2669902 - 231 WP_094963399.1 DUF905 domain-containing protein -
NBY30_RS12870 (2669926) 2669926..2670750 - 825 WP_049594226.1 DUF932 domain-containing protein -
NBY30_RS12875 (2671288) 2671288..2671920 + 633 WP_094963400.1 inovirus Gp2 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(15-114)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14411.53 Da        Isoelectric Point: 9.8627

>T246796 WP_065523303.1 NZ_CP098169:c2667982-2667593 [Klebsiella pneumoniae]
MQTKSSPLMRAASSRPSPVYIWQTLLTSLLAQHYGLTLSDTPFSDEQVIQQHIDAGISLVDALNFIVEKYELVRTDRPGF
SILTQSPFITPIDILRARKATGLMNRDTYKEVTAITRGQHPQVSAPGKR

Download         Length: 390 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13440.36 Da        Isoelectric Point: 7.4002

>AT246796 WP_049594224.1 NZ_CP098169:c2668398-2668039 [Klebsiella pneumoniae]
MSKKTTITTHDISEPWWGLRRSVSPCFGARLVQERNRLHYLADRANFDGQFCDADLRHLDQAFPVLLKQLELMLTSGELN
PRHQHGIILYAKGLTCEADTLGSHGYVYIAIYPTPVATA

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A443UJW7

Antitoxin

Source ID Structure
AlphaFold DB A0A443UJP3

References