Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 1817756..1818381 Replicon chromosome
Accession NZ_CP098169
Organism Klebsiella pneumoniae strain Z0117KP0003

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag NBY30_RS08605 Protein ID WP_002882817.1
Coordinates 1817756..1818139 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag NBY30_RS08610 Protein ID WP_004150355.1
Coordinates 1818139..1818381 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY30_RS08590 (1815122) 1815122..1816024 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
NBY30_RS08595 (1816021) 1816021..1816656 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
NBY30_RS08600 (1816653) 1816653..1817582 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
NBY30_RS08605 (1817756) 1817756..1818139 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
NBY30_RS08610 (1818139) 1818139..1818381 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
NBY30_RS08615 (1818586) 1818586..1819503 + 918 WP_021466676.1 alpha/beta hydrolase -
NBY30_RS08620 (1819517) 1819517..1820458 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
NBY30_RS08625 (1820503) 1820503..1820940 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
NBY30_RS08630 (1820937) 1820937..1821797 - 861 WP_004146232.1 virulence factor BrkB family protein -
NBY30_RS08635 (1821791) 1821791..1822390 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T246793 WP_002882817.1 NZ_CP098169:c1818139-1817756 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT246793 WP_004150355.1 NZ_CP098169:c1818381-1818139 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References