Detailed information of TA system TA246792

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 1486664..1488345
• Replicon: chromosome
• Accession: NZ_CP098169
• Organism: Klebsiella pneumoniae strain Z0117KP0003

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A6TH06
• Locus tag: NBY30_RS07055
• Protein ID: WP_015959269.1
• Coordinates: 1486664..1487539 (-)
• Length: 292 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: NBY30_RS07060
• Protein ID: WP_004177809.1
• Coordinates: 1487587..1488345 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NBY30_RS07035 (1481970)	1481970..1483490	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
NBY30_RS07040 (1483487)	1483487..1484485	+	999	WP_002885172.1	ribose ABC transporter permease	-
NBY30_RS07045 (1484516)	1484516..1485457	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
NBY30_RS07050 (1485532)	1485532..1486539	+	1008	WP_015959270.1	carbohydrate kinase family protein	-
NBY30_RS07055 (1486664)	1486664..1487539	-	876	WP_015959269.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
NBY30_RS07060 (1487587)	1487587..1488345	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
NBY30_RS07065 (1488431)	1488431..1489159	-	729	WP_032413197.1	response regulator transcription factor	-
NBY30_RS07070 (1489432)	1489432..1491579	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
NBY30_RS07075 (1491576)	1491576..1491719	-	144	WP_162897205.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (7-264)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 292 a.a.
• Molecular weight: 32990.17 Da
• Isoelectric Point: 5.4637

>T246792 WP_015959269.1 NZ_CP098169:c1487539-1486664 [Klebsiella pneumoniae]
MQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQAGMSAVLQANRSDE
MRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQHPRDFYDVKLLLDAQ
ELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKSCITQQDVDFLLSFK
RGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 876 bp

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT246792 WP_004177809.1 NZ_CP098169:c1488345-1487587 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

Structures

Toxin

• AlphaFold DB: A6TH06

Antitoxin

• AlphaFold DB: A6TH05