Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 1215490..1216300 Replicon chromosome
Accession NZ_CP098169
Organism Klebsiella pneumoniae strain Z0117KP0003

Toxin (Protein)


Gene name KacT Uniprot ID A0A0H3GMP0
Locus tag NBY30_RS05755 Protein ID WP_002887280.1
Coordinates 1215490..1216023 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag NBY30_RS05760 Protein ID WP_002887278.1
Coordinates 1216034..1216300 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY30_RS05750 (1214322) 1214322..1215443 + 1122 WP_009309849.1 cupin domain-containing protein -
NBY30_RS05755 (1215490) 1215490..1216023 - 534 WP_002887280.1 type II toxin-antitoxin system toxin KacT Toxin
NBY30_RS05760 (1216034) 1216034..1216300 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
NBY30_RS05765 (1216403) 1216403..1217836 - 1434 WP_023288193.1 Cu(+)/Ag(+) sensor histidine kinase -
NBY30_RS05770 (1217826) 1217826..1218509 - 684 WP_032105399.1 copper response regulator transcription factor CusR -
NBY30_RS05775 (1218682) 1218682..1220067 + 1386 WP_032431458.1 efflux transporter outer membrane subunit -
NBY30_RS05780 (1220085) 1220085..1220390 + 306 WP_032432083.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19838.70 Da        Isoelectric Point: 5.2614

>T246790 WP_002887280.1 NZ_CP098169:c1216023-1215490 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHVMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT246790 WP_002887278.1 NZ_CP098169:c1216300-1216034 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5ZGN
PDB 5XUN

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References