Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4986764..4988445 Replicon chromosome
Accession NZ_CP098167
Organism Klebsiella pneumoniae strain Z0117KP0004

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag NBY32_RS24120 Protein ID WP_002885155.1
Coordinates 4986764..4987681 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A6TH05
Locus tag NBY32_RS24125 Protein ID WP_004177809.1
Coordinates 4987687..4988445 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY32_RS24100 (4982070) 4982070..4983590 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
NBY32_RS24105 (4983587) 4983587..4984585 + 999 WP_002885172.1 ribose ABC transporter permease -
NBY32_RS24110 (4984616) 4984616..4985557 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
NBY32_RS24115 (4985632) 4985632..4986639 + 1008 WP_004177805.1 carbohydrate kinase family protein -
NBY32_RS24120 (4986764) 4986764..4987681 - 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
NBY32_RS24125 (4987687) 4987687..4988445 - 759 WP_004177809.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
NBY32_RS24130 (4988531) 4988531..4989259 - 729 WP_004177810.1 response regulator transcription factor -
NBY32_RS24135 (4989532) 4989532..4991679 + 2148 WP_077598921.1 formate dehydrogenase subunit alpha -
NBY32_RS24140 (4991909) 4991909..4992595 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T246786 WP_002885155.1 NZ_CP098167:c4987681-4986764 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28548.92 Da        Isoelectric Point: 10.0870

>AT246786 WP_004177809.1 NZ_CP098167:c4988445-4987687 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A6TH05

References