Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 4733573..4734276 Replicon chromosome
Accession NZ_CP098167
Organism Klebsiella pneumoniae strain Z0117KP0004

Toxin (Protein)


Gene name ykfI Uniprot ID A0A939NMR5
Locus tag NBY32_RS22920 Protein ID WP_071994632.1
Coordinates 4733573..4733914 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A939NIK9
Locus tag NBY32_RS22925 Protein ID WP_032434296.1
Coordinates 4733935..4734276 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY32_RS22910 (4729888) 4729888..4730757 + 870 WP_023317468.1 HNH endonuclease -
NBY32_RS22915 (4731348) 4731348..4733381 + 2034 WP_050598589.1 hypothetical protein -
NBY32_RS22920 (4733573) 4733573..4733914 - 342 WP_071994632.1 TA system toxin CbtA family protein Toxin
NBY32_RS22925 (4733935) 4733935..4734276 - 342 WP_032434296.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
NBY32_RS22930 (4734287) 4734287..4734829 - 543 WP_032434298.1 DNA repair protein RadC -
NBY32_RS22935 (4734842) 4734842..4735282 - 441 WP_032434300.1 antirestriction protein -
NBY32_RS22940 (4735313) 4735313..4736134 - 822 WP_032434301.1 DUF932 domain-containing protein -
NBY32_RS22945 (4736254) 4736254..4736727 - 474 WP_032434303.1 hypothetical protein -
NBY32_RS22950 (4736799) 4736799..4737251 - 453 WP_032410767.1 hypothetical protein -
NBY32_RS22955 (4737287) 4737287..4738003 - 717 WP_032434305.1 WYL domain-containing protein -
NBY32_RS22960 (4738247) 4738247..4739121 - 875 Protein_4503 GTPase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4721870..4767543 45673


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(13-112)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12789.77 Da        Isoelectric Point: 9.6552

>T246784 WP_071994632.1 NZ_CP098167:c4733914-4733573 [Klebsiella pneumoniae]
MKTLPATTPQAVTLCLSSVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRKGF
NWQEHSPYLRAVDILRARQATGLLRRSRKNAVR

Download         Length: 342 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12893.40 Da        Isoelectric Point: 5.9612

>AT246784 WP_032434296.1 NZ_CP098167:c4734276-4733935 [Klebsiella pneumoniae]
MKSTDSENDSFLKWGLNRNVTPCFGARLVQEGNRLHYLADRASITGEFSNAESLKLDEVFPHFISQMESMLTTGEMNPRH
AHFFTLYHNGFTCEADTLGSYGYVYIAVYPTQR

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References