Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1895779..1896391 Replicon chromosome
Accession NC_013961
Organism Erwinia amylovora CFBP1430

Toxin (Protein)


Gene name hicA Uniprot ID D2TUP9
Locus tag EAMY_RS25850 Protein ID WP_012906750.1
Coordinates 1895779..1895958 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID D4I356
Locus tag EAMY_RS25855 Protein ID WP_004157632.1
Coordinates 1895981..1896391 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EAMY_RS25830 1891337..1892287 + 951 WP_004157624.1 DUF1471 domain-containing protein -
EAMY_RS25835 1892495..1893886 + 1392 WP_004157625.1 amino acid permease -
EAMY_RS25840 1893890..1894354 - 465 WP_004157626.1 hypothetical protein -
EAMY_RS25845 1894531..1895259 + 729 WP_004157629.1 two-component system response regulator RstA -
EAMY_RS25850 1895779..1895958 + 180 WP_012906750.1 type II toxin-antitoxin system HicA family toxin Toxin
EAMY_RS25855 1895981..1896391 + 411 WP_004157632.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EAMY_RS25860 1896447..1897448 + 1002 WP_004157633.1 acyltransferase -
EAMY_RS35020 1898319..1898531 - 213 WP_004157635.1 hypothetical protein -
EAMY_RS36340 1898789..1898962 - 174 WP_004157636.1 hypothetical protein -
EAMY_RS36170 1899057..1899230 - 174 WP_013036045.1 hypothetical protein -
EAMY_RS25865 1899241..1899513 - 273 WP_004157637.1 hypothetical protein -
EAMY_RS25875 1900119..1900733 + 615 WP_004165438.1 acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1889617..1909157 19540


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6644.85 Da        Isoelectric Point: 10.9132

>T24678 WP_012906750.1 NC_013961:1895779-1895958 [Erwinia amylovora CFBP1430]
MDSRNAIAMIEADGWYLVRVKGSHHQFKHPTKKGLVTVKHPQKDIPLPTLKSIKKQAGL

Download         Length: 180 bp

>T24678 NC_013961:1895779-1895958 [Erwinia amylovora CFBP1430]
ATGGATAGCAGGAATGCAATAGCAATGATAGAGGCCGATGGATGGTATCTGGTGAGAGTAAAAGGCAGTCATCACCAGTT
CAAGCACCCAACGAAAAAAGGGCTGGTAACGGTAAAACATCCCCAAAAGGACATACCGCTACCAACGCTGAAAAGCATTA
AAAAACAGGCGGGGCTTTAA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14829.76 Da        Isoelectric Point: 4.3623

>AT24678 WP_004157632.1 NC_013961:1895981-1896391 [Erwinia amylovora CFBP1430]
MLYPVAIDKGDSSFGVRVPDIPGCFSGGDNYQDAIESAREAIDAHIELLVEDGEAVPEATSVENWLADPDYVGVVWALVD
VDVTRLMGKAEKINVTLPSLLIRRIDQFVAAHPEYGSRSGFLSRVAADKVIGREKR

Download         Length: 411 bp

>AT24678 NC_013961:1895981-1896391 [Erwinia amylovora CFBP1430]
ATGTTATACCCTGTTGCTATTGATAAAGGCGATTCATCCTTCGGCGTTCGCGTACCCGATATTCCAGGCTGCTTCTCTGG
CGGCGACAATTATCAGGATGCGATTGAGAGCGCGCGTGAGGCTATCGACGCGCATATCGAATTACTGGTGGAAGATGGCG
AAGCGGTGCCGGAAGCGACCAGCGTGGAAAACTGGCTGGCCGATCCCGATTATGTTGGTGTGGTGTGGGCGCTGGTAGAT
GTGGACGTTACCCGGCTGATGGGGAAAGCGGAAAAAATCAATGTTACGCTCCCTTCTTTACTGATCCGCCGTATCGATCA
GTTTGTCGCTGCACATCCTGAGTACGGTAGCCGTTCCGGCTTCCTGTCCCGCGTGGCGGCTGATAAAGTGATTGGTCGCG
AAAAACGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D6XDK4

Antitoxin

Source ID Structure
AlphaFold DB A0A830ZVY0

References