Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 862855..863512 Replicon chromosome
Accession NZ_CP098167
Organism Klebsiella pneumoniae strain Z0117KP0004

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag NBY32_RS04340 Protein ID WP_002916310.1
Coordinates 863102..863512 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag NBY32_RS04335 Protein ID WP_002916312.1
Coordinates 862855..863121 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY32_RS04310 (858063) 858063..859496 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
NBY32_RS04315 (859615) 859615..860343 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
NBY32_RS04320 (860393) 860393..860704 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
NBY32_RS04325 (860868) 860868..861527 + 660 WP_004174454.1 hemolysin III family protein -
NBY32_RS04330 (861626) 861626..862609 - 984 WP_023286864.1 tRNA-modifying protein YgfZ -
NBY32_RS04335 (862855) 862855..863121 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
NBY32_RS04340 (863102) 863102..863512 + 411 WP_002916310.1 protein YgfX Toxin
NBY32_RS04345 (863519) 863519..864040 - 522 WP_002916308.1 flavodoxin FldB -
NBY32_RS04350 (864141) 864141..865037 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
NBY32_RS04355 (865060) 865060..865773 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NBY32_RS04360 (865779) 865779..867512 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T246775 WP_002916310.1 NZ_CP098167:863102-863512 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT246775 WP_002916312.1 NZ_CP098167:862855-863121 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References