Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4492577..4493234 Replicon chromosome
Accession NZ_CP098165
Organism Klebsiella pneumoniae strain Z0117KP0005

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag NBY34_RS21485 Protein ID WP_002916310.1
Coordinates 4492577..4492987 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag NBY34_RS21490 Protein ID WP_002916312.1
Coordinates 4492968..4493234 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY34_RS21465 (4488577) 4488577..4490310 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
NBY34_RS21470 (4490316) 4490316..4491029 - 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NBY34_RS21475 (4491052) 4491052..4491948 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
NBY34_RS21480 (4492049) 4492049..4492570 + 522 WP_002916308.1 flavodoxin FldB -
NBY34_RS21485 (4492577) 4492577..4492987 - 411 WP_002916310.1 protein YgfX Toxin
NBY34_RS21490 (4492968) 4492968..4493234 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
NBY34_RS21495 (4493480) 4493480..4494463 + 984 WP_023286864.1 tRNA-modifying protein YgfZ -
NBY34_RS21500 (4494562) 4494562..4495221 - 660 WP_004174454.1 hemolysin III family protein -
NBY34_RS21505 (4495385) 4495385..4495696 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
NBY34_RS21510 (4495746) 4495746..4496474 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
NBY34_RS21515 (4496593) 4496593..4498026 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T246769 WP_002916310.1 NZ_CP098165:c4492987-4492577 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT246769 WP_002916312.1 NZ_CP098165:c4493234-4492968 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References