Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2574822..2576410 Replicon chromosome
Accession NZ_CP098165
Organism Klebsiella pneumoniae strain Z0117KP0005

Toxin (Protein)


Gene name hipA Uniprot ID A0A9J6RYF8
Locus tag NBY34_RS12185 Protein ID WP_004892016.1
Coordinates 2575088..2576410 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NBY34_RS12180 Protein ID WP_004176198.1
Coordinates 2574822..2575088 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY34_RS12155 (2569851) 2569851..2570774 + 924 WP_008804925.1 LysR family hpxDE operon transcriptional regulator HpxR -
NBY34_RS12160 (2570755) 2570755..2571909 - 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
NBY34_RS12165 (2572255) 2572255..2573634 + 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
NBY34_RS12170 (2573612) 2573612..2574112 + 501 WP_032435339.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
NBY34_RS12175 (2574109) 2574109..2574435 + 327 WP_004184023.1 hydroxyisourate hydrolase -
NBY34_RS12180 (2574822) 2574822..2575088 + 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NBY34_RS12185 (2575088) 2575088..2576410 + 1323 WP_004892016.1 type II toxin-antitoxin system HipA family toxin Toxin
NBY34_RS12190 (2576427) 2576427..2577719 - 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
NBY34_RS12195 (2577861) 2577861..2578865 - 1005 WP_032435338.1 fimbrial protein -
NBY34_RS12200 (2578853) 2578853..2581354 - 2502 WP_032435337.1 fimbria/pilus outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49141.44 Da        Isoelectric Point: 7.5357

>T246763 WP_004892016.1 NZ_CP098165:2575088-2576410 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT246763 WP_004176198.1 NZ_CP098165:2574822-2575088 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References