Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 652327..653137 Replicon chromosome
Accession NZ_CP098165
Organism Klebsiella pneumoniae strain Z0117KP0005

Toxin (Protein)


Gene name KacT Uniprot ID A0A060VJ83
Locus tag NBY34_RS03040 Protein ID WP_004178461.1
Coordinates 652604..653137 (+) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag NBY34_RS03035 Protein ID WP_002887278.1
Coordinates 652327..652593 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY34_RS03015 (648198) 648198..648542 - 345 WP_004894569.1 cation efflux system protein CusF -
NBY34_RS03020 (648560) 648560..649945 - 1386 WP_026005908.1 efflux transporter outer membrane subunit -
NBY34_RS03025 (650118) 650118..650801 + 684 WP_002887273.1 copper response regulator transcription factor CusR -
NBY34_RS03030 (650791) 650791..652224 + 1434 WP_004186848.1 Cu(+)/Ag(+) sensor histidine kinase -
NBY34_RS03035 (652327) 652327..652593 + 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
NBY34_RS03040 (652604) 652604..653137 + 534 WP_004178461.1 type II toxin-antitoxin system toxin KacT Toxin
NBY34_RS03045 (653185) 653185..654306 - 1122 WP_004186850.1 cupin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19810.65 Da        Isoelectric Point: 5.2614

>T246761 WP_004178461.1 NZ_CP098165:652604-653137 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT246761 WP_002887278.1 NZ_CP098165:652327-652593 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060VJ83

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References