Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 529229..529745 Replicon chromosome
Accession NZ_CP098165
Organism Klebsiella pneumoniae strain Z0117KP0005

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag NBY34_RS02515 Protein ID WP_004178374.1
Coordinates 529461..529745 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A919M0P8
Locus tag NBY34_RS02510 Protein ID WP_032434351.1
Coordinates 529229..529471 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY34_RS02495 (525258) 525258..525998 + 741 WP_002886899.1 KDGP aldolase family protein -
NBY34_RS02500 (526064) 526064..527218 + 1155 WP_002886900.1 lactonase family protein -
NBY34_RS02505 (527241) 527241..529151 + 1911 WP_004152270.1 PRD domain-containing protein -
NBY34_RS02510 (529229) 529229..529471 + 243 WP_032434351.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NBY34_RS02515 (529461) 529461..529745 + 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NBY34_RS02520 (529749) 529749..530213 - 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NBY34_RS02525 (530455) 530455..532593 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
NBY34_RS02530 (532950) 532950..533693 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
NBY34_RS02535 (533696) 533696..533869 - 174 WP_032414379.1 hypothetical protein -
NBY34_RS02540 (533999) 533999..534262 + 264 WP_014908078.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-68)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T246759 WP_004178374.1 NZ_CP098165:529461-529745 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9003.47 Da        Isoelectric Point: 6.3340

>AT246759 WP_032434351.1 NZ_CP098165:529229-529471 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGGKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure

References