Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 367601..369282 Replicon chromosome
Accession NZ_CP098165
Organism Klebsiella pneumoniae strain Z0117KP0005

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag NBY34_RS01710 Protein ID WP_002885155.1
Coordinates 368365..369282 (+) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A6TH05
Locus tag NBY34_RS01705 Protein ID WP_004177809.1
Coordinates 367601..368359 (+) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY34_RS01690 (363451) 363451..364137 - 687 WP_004151733.1 tetratricopeptide repeat protein -
NBY34_RS01695 (364367) 364367..366514 - 2148 WP_077598921.1 formate dehydrogenase subunit alpha -
NBY34_RS01700 (366787) 366787..367515 + 729 WP_004177810.1 response regulator transcription factor -
NBY34_RS01705 (367601) 367601..368359 + 759 WP_004177809.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
NBY34_RS01710 (368365) 368365..369282 + 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
NBY34_RS01715 (369407) 369407..370414 - 1008 WP_004177805.1 carbohydrate kinase family protein -
NBY34_RS01720 (370489) 370489..371430 - 942 WP_002885156.1 ABC transporter substrate-binding protein -
NBY34_RS01725 (371461) 371461..372459 - 999 WP_002885172.1 ribose ABC transporter permease -
NBY34_RS01730 (372456) 372456..373976 - 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T246758 WP_002885155.1 NZ_CP098165:368365-369282 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28548.92 Da        Isoelectric Point: 10.0870

>AT246758 WP_004177809.1 NZ_CP098165:367601-368359 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A6TH05

References