Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4492518..4493175 Replicon chromosome
Accession NZ_CP098161
Organism Klebsiella pneumoniae strain Z0117KP0006

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag NBY36_RS21490 Protein ID WP_002916310.1
Coordinates 4492518..4492928 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag NBY36_RS21495 Protein ID WP_002916312.1
Coordinates 4492909..4493175 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY36_RS21470 (4488518) 4488518..4490251 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
NBY36_RS21475 (4490257) 4490257..4490970 - 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NBY36_RS21480 (4490993) 4490993..4491889 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
NBY36_RS21485 (4491990) 4491990..4492511 + 522 WP_002916308.1 flavodoxin FldB -
NBY36_RS21490 (4492518) 4492518..4492928 - 411 WP_002916310.1 protein YgfX Toxin
NBY36_RS21495 (4492909) 4492909..4493175 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
NBY36_RS21500 (4493421) 4493421..4494404 + 984 WP_023286864.1 tRNA-modifying protein YgfZ -
NBY36_RS21505 (4494503) 4494503..4495162 - 660 WP_004174454.1 hemolysin III family protein -
NBY36_RS21510 (4495326) 4495326..4495637 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
NBY36_RS21515 (4495687) 4495687..4496415 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
NBY36_RS21520 (4496534) 4496534..4497967 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T246753 WP_002916310.1 NZ_CP098161:c4492928-4492518 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT246753 WP_002916312.1 NZ_CP098161:c4493175-4492909 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References