Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2574758..2576346 Replicon chromosome
Accession NZ_CP098161
Organism Klebsiella pneumoniae strain Z0117KP0006

Toxin (Protein)


Gene name hipA Uniprot ID A0A9J6RYF8
Locus tag NBY36_RS12190 Protein ID WP_004892016.1
Coordinates 2575024..2576346 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NBY36_RS12185 Protein ID WP_004176198.1
Coordinates 2574758..2575024 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY36_RS12160 (2569787) 2569787..2570710 + 924 WP_008804925.1 LysR family hpxDE operon transcriptional regulator HpxR -
NBY36_RS12165 (2570691) 2570691..2571845 - 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
NBY36_RS12170 (2572191) 2572191..2573570 + 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
NBY36_RS12175 (2573548) 2573548..2574048 + 501 WP_032435339.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
NBY36_RS12180 (2574045) 2574045..2574371 + 327 WP_004184023.1 hydroxyisourate hydrolase -
NBY36_RS12185 (2574758) 2574758..2575024 + 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NBY36_RS12190 (2575024) 2575024..2576346 + 1323 WP_004892016.1 type II toxin-antitoxin system HipA family toxin Toxin
NBY36_RS12195 (2576363) 2576363..2577655 - 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
NBY36_RS12200 (2577797) 2577797..2578801 - 1005 WP_032435338.1 fimbrial protein -
NBY36_RS12205 (2578789) 2578789..2581290 - 2502 WP_032435337.1 fimbria/pilus outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49141.44 Da        Isoelectric Point: 7.5357

>T246747 WP_004892016.1 NZ_CP098161:2575024-2576346 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT246747 WP_004176198.1 NZ_CP098161:2574758-2575024 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References