Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 621752..622455 Replicon chromosome
Accession NZ_CP098161
Organism Klebsiella pneumoniae strain Z0117KP0006

Toxin (Protein)


Gene name ykfI Uniprot ID A0A939NMR5
Locus tag NBY36_RS02905 Protein ID WP_071994632.1
Coordinates 622114..622455 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A939NIK9
Locus tag NBY36_RS02900 Protein ID WP_032434296.1
Coordinates 621752..622093 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY36_RS02865 (616907) 616907..617781 + 875 Protein_539 GTPase family protein -
NBY36_RS02870 (618025) 618025..618741 + 717 WP_032434305.1 WYL domain-containing protein -
NBY36_RS02875 (618777) 618777..619229 + 453 WP_032410767.1 hypothetical protein -
NBY36_RS02880 (619301) 619301..619774 + 474 WP_032434303.1 hypothetical protein -
NBY36_RS02885 (619894) 619894..620715 + 822 WP_032434301.1 DUF932 domain-containing protein -
NBY36_RS02890 (620746) 620746..621186 + 441 WP_032434300.1 antirestriction protein -
NBY36_RS02895 (621199) 621199..621741 + 543 WP_032434298.1 DNA repair protein RadC -
NBY36_RS02900 (621752) 621752..622093 + 342 WP_032434296.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
NBY36_RS02905 (622114) 622114..622455 + 342 WP_071994632.1 TA system toxin CbtA family protein Toxin
NBY36_RS02910 (622647) 622647..624680 - 2034 WP_050598589.1 hypothetical protein -
NBY36_RS02915 (625271) 625271..626140 - 870 WP_023317468.1 HNH endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 589158..634736 45578


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(13-112)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12789.77 Da        Isoelectric Point: 9.6552

>T246744 WP_071994632.1 NZ_CP098161:622114-622455 [Klebsiella pneumoniae]
MKTLPATTPQAVTLCLSSVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRKGF
NWQEHSPYLRAVDILRARQATGLLRRSRKNAVR

Download         Length: 342 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12893.40 Da        Isoelectric Point: 5.9612

>AT246744 WP_032434296.1 NZ_CP098161:621752-622093 [Klebsiella pneumoniae]
MKSTDSENDSFLKWGLNRNVTPCFGARLVQEGNRLHYLADRASITGEFSNAESLKLDEVFPHFISQMESMLTTGEMNPRH
AHFFTLYHNGFTCEADTLGSYGYVYIAVYPTQR

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References