Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 44673..45298 Replicon chromosome
Accession NZ_CP098161
Organism Klebsiella pneumoniae strain Z0117KP0006

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag NBY36_RS00205 Protein ID WP_002882817.1
Coordinates 44915..45298 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag NBY36_RS00200 Protein ID WP_004150355.1
Coordinates 44673..44915 (+) Length 81 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY36_RS00175 (40664) 40664..41263 + 600 WP_004151865.1 glucose-1-phosphatase -
NBY36_RS00180 (41257) 41257..42117 + 861 WP_004146232.1 virulence factor BrkB family protein -
NBY36_RS00185 (42114) 42114..42551 + 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
NBY36_RS00190 (42596) 42596..43537 + 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
NBY36_RS00195 (43551) 43551..44468 - 918 WP_009484979.1 alpha/beta hydrolase -
NBY36_RS00200 (44673) 44673..44915 + 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
NBY36_RS00205 (44915) 44915..45298 + 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
NBY36_RS00210 (45472) 45472..46401 - 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
NBY36_RS00215 (46398) 46398..47033 - 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
NBY36_RS00220 (47030) 47030..47932 - 903 WP_002882822.1 formate dehydrogenase subunit beta -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(7-112)

Antitoxin

(16-47)


Sequences


Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T246741 WP_002882817.1 NZ_CP098161:44915-45298 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp


Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT246741 WP_004150355.1 NZ_CP098161:44673-44915 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8


Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References