Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 4733538..4734241 Replicon chromosome
Accession NZ_CP098159
Organism Klebsiella pneumoniae strain Z0117KP0008

Toxin (Protein)


Gene name ykfI Uniprot ID A0A939NMR5
Locus tag NBY40_RS22920 Protein ID WP_071994632.1
Coordinates 4733538..4733879 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A939NIK9
Locus tag NBY40_RS22925 Protein ID WP_032434296.1
Coordinates 4733900..4734241 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY40_RS22910 (4729853) 4729853..4730722 + 870 WP_023317468.1 HNH endonuclease -
NBY40_RS22915 (4731313) 4731313..4733346 + 2034 WP_050598589.1 hypothetical protein -
NBY40_RS22920 (4733538) 4733538..4733879 - 342 WP_071994632.1 TA system toxin CbtA family protein Toxin
NBY40_RS22925 (4733900) 4733900..4734241 - 342 WP_032434296.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
NBY40_RS22930 (4734252) 4734252..4734794 - 543 WP_032434298.1 DNA repair protein RadC -
NBY40_RS22935 (4734807) 4734807..4735247 - 441 WP_032434300.1 antirestriction protein -
NBY40_RS22940 (4735278) 4735278..4736099 - 822 WP_032434301.1 DUF932 domain-containing protein -
NBY40_RS22945 (4736219) 4736219..4736692 - 474 WP_032434303.1 hypothetical protein -
NBY40_RS22950 (4736764) 4736764..4737216 - 453 WP_032410767.1 hypothetical protein -
NBY40_RS22955 (4737252) 4737252..4737968 - 717 WP_032434305.1 WYL domain-containing protein -
NBY40_RS22960 (4738212) 4738212..4739086 - 875 Protein_4503 GTPase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4721835..4767508 45673


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(13-112)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12789.77 Da        Isoelectric Point: 9.6552

>T246736 WP_071994632.1 NZ_CP098159:c4733879-4733538 [Klebsiella pneumoniae]
MKTLPATTPQAVTLCLSSVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRKGF
NWQEHSPYLRAVDILRARQATGLLRRSRKNAVR

Download         Length: 342 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12893.40 Da        Isoelectric Point: 5.9612

>AT246736 WP_032434296.1 NZ_CP098159:c4734241-4733900 [Klebsiella pneumoniae]
MKSTDSENDSFLKWGLNRNVTPCFGARLVQEGNRLHYLADRASITGEFSNAESLKLDEVFPHFISQMESMLTTGEMNPRH
AHFFTLYHNGFTCEADTLGSYGYVYIAVYPTQR

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References