Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4702874..4703684 Replicon chromosome
Accession NZ_CP098159
Organism Klebsiella pneumoniae strain Z0117KP0008

Toxin (Protein)


Gene name KacT Uniprot ID A0A060VJ83
Locus tag NBY40_RS22785 Protein ID WP_004178461.1
Coordinates 4702874..4703407 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag NBY40_RS22790 Protein ID WP_002887278.1
Coordinates 4703418..4703684 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY40_RS22780 (4701705) 4701705..4702826 + 1122 WP_004186850.1 cupin domain-containing protein -
NBY40_RS22785 (4702874) 4702874..4703407 - 534 WP_004178461.1 type II toxin-antitoxin system toxin KacT Toxin
NBY40_RS22790 (4703418) 4703418..4703684 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
NBY40_RS22795 (4703787) 4703787..4705220 - 1434 WP_004186848.1 Cu(+)/Ag(+) sensor histidine kinase -
NBY40_RS22800 (4705210) 4705210..4705893 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
NBY40_RS22805 (4706066) 4706066..4707451 + 1386 WP_026005908.1 efflux transporter outer membrane subunit -
NBY40_RS22810 (4707469) 4707469..4707813 + 345 WP_004894569.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19810.65 Da        Isoelectric Point: 5.2614

>T246735 WP_004178461.1 NZ_CP098159:c4703407-4702874 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT246735 WP_002887278.1 NZ_CP098159:c4703684-4703418 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060VJ83

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References