Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 862769..863426 Replicon chromosome
Accession NZ_CP098159
Organism Klebsiella pneumoniae strain Z0117KP0008

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag NBY40_RS04340 Protein ID WP_002916310.1
Coordinates 863016..863426 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag NBY40_RS04335 Protein ID WP_002916312.1
Coordinates 862769..863035 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY40_RS04310 (857977) 857977..859410 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
NBY40_RS04315 (859529) 859529..860257 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
NBY40_RS04320 (860307) 860307..860618 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
NBY40_RS04325 (860782) 860782..861441 + 660 WP_004174454.1 hemolysin III family protein -
NBY40_RS04330 (861540) 861540..862523 - 984 WP_023286864.1 tRNA-modifying protein YgfZ -
NBY40_RS04335 (862769) 862769..863035 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
NBY40_RS04340 (863016) 863016..863426 + 411 WP_002916310.1 protein YgfX Toxin
NBY40_RS04345 (863433) 863433..863954 - 522 WP_002916308.1 flavodoxin FldB -
NBY40_RS04350 (864055) 864055..864951 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
NBY40_RS04355 (864974) 864974..865687 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NBY40_RS04360 (865693) 865693..867426 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T246727 WP_002916310.1 NZ_CP098159:863016-863426 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT246727 WP_002916312.1 NZ_CP098159:862769-863035 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References