Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4958942..4960623 Replicon chromosome
Accession NZ_CP098149
Organism Klebsiella pneumoniae strain Z0117KP0019

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag NBY46_RS24100 Protein ID WP_002885155.1
Coordinates 4958942..4959859 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A6TH05
Locus tag NBY46_RS24105 Protein ID WP_004177809.1
Coordinates 4959865..4960623 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY46_RS24080 (4954248) 4954248..4955768 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
NBY46_RS24085 (4955765) 4955765..4956763 + 999 WP_002885172.1 ribose ABC transporter permease -
NBY46_RS24090 (4956794) 4956794..4957735 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
NBY46_RS24095 (4957810) 4957810..4958817 + 1008 WP_004177805.1 carbohydrate kinase family protein -
NBY46_RS24100 (4958942) 4958942..4959859 - 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
NBY46_RS24105 (4959865) 4959865..4960623 - 759 WP_004177809.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
NBY46_RS24110 (4960709) 4960709..4961437 - 729 WP_004177810.1 response regulator transcription factor -
NBY46_RS24115 (4961710) 4961710..4963857 + 2148 WP_077598921.1 formate dehydrogenase subunit alpha -
NBY46_RS24120 (4964087) 4964087..4964773 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T246723 WP_002885155.1 NZ_CP098149:c4959859-4958942 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28548.92 Da        Isoelectric Point: 10.0870

>AT246723 WP_004177809.1 NZ_CP098149:c4960623-4959865 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A6TH05

References