Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4795424..4795940 Replicon chromosome
Accession NZ_CP098149
Organism Klebsiella pneumoniae strain Z0117KP0019

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag NBY46_RS23275 Protein ID WP_004178374.1
Coordinates 4795424..4795708 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A919M0P8
Locus tag NBY46_RS23280 Protein ID WP_032434351.1
Coordinates 4795698..4795940 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY46_RS23250 (4790907) 4790907..4791170 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
NBY46_RS23255 (4791300) 4791300..4791473 + 174 WP_032414379.1 hypothetical protein -
NBY46_RS23260 (4791476) 4791476..4792219 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
NBY46_RS23265 (4792576) 4792576..4794714 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
NBY46_RS23270 (4794956) 4794956..4795420 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NBY46_RS23275 (4795424) 4795424..4795708 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NBY46_RS23280 (4795698) 4795698..4795940 - 243 WP_032434351.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NBY46_RS23285 (4796018) 4796018..4797928 - 1911 WP_004152270.1 PRD domain-containing protein -
NBY46_RS23290 (4797951) 4797951..4799105 - 1155 WP_002886900.1 lactonase family protein -
NBY46_RS23295 (4799171) 4799171..4799911 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-68)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T246722 WP_004178374.1 NZ_CP098149:c4795708-4795424 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9003.47 Da        Isoelectric Point: 6.3340

>AT246722 WP_032434351.1 NZ_CP098149:c4795940-4795698 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGGKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure

References