Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 4702696..4703399 Replicon chromosome
Accession NZ_CP098149
Organism Klebsiella pneumoniae strain Z0117KP0019

Toxin (Protein)


Gene name ykfI Uniprot ID A0A939NMR5
Locus tag NBY46_RS22880 Protein ID WP_071994632.1
Coordinates 4702696..4703037 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A939NIK9
Locus tag NBY46_RS22885 Protein ID WP_032434296.1
Coordinates 4703058..4703399 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY46_RS22870 (4699011) 4699011..4699880 + 870 WP_023317468.1 HNH endonuclease -
NBY46_RS22875 (4700471) 4700471..4702504 + 2034 WP_050598589.1 hypothetical protein -
NBY46_RS22880 (4702696) 4702696..4703037 - 342 WP_071994632.1 TA system toxin CbtA family protein Toxin
NBY46_RS22885 (4703058) 4703058..4703399 - 342 WP_032434296.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
NBY46_RS22890 (4703410) 4703410..4703952 - 543 WP_032434298.1 DNA repair protein RadC -
NBY46_RS22895 (4703965) 4703965..4704405 - 441 WP_032434300.1 antirestriction protein -
NBY46_RS22900 (4704436) 4704436..4705257 - 822 WP_032434301.1 DUF932 domain-containing protein -
NBY46_RS22905 (4705377) 4705377..4705850 - 474 WP_032434303.1 hypothetical protein -
NBY46_RS22910 (4705922) 4705922..4706374 - 453 WP_032410767.1 hypothetical protein -
NBY46_RS22915 (4706410) 4706410..4707126 - 717 WP_032434305.1 WYL domain-containing protein -
NBY46_RS22920 (4707370) 4707370..4708244 - 875 Protein_4495 GTPase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4690993..4736666 45673


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(13-112)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12789.77 Da        Isoelectric Point: 9.6552

>T246721 WP_071994632.1 NZ_CP098149:c4703037-4702696 [Klebsiella pneumoniae]
MKTLPATTPQAVTLCLSSVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRKGF
NWQEHSPYLRAVDILRARQATGLLRRSRKNAVR

Download         Length: 342 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12893.40 Da        Isoelectric Point: 5.9612

>AT246721 WP_032434296.1 NZ_CP098149:c4703399-4703058 [Klebsiella pneumoniae]
MKSTDSENDSFLKWGLNRNVTPCFGARLVQEGNRLHYLADRASITGEFSNAESLKLDEVFPHFISQMESMLTTGEMNPRH
AHFFTLYHNGFTCEADTLGSYGYVYIAVYPTQR

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References