Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4672032..4672842 Replicon chromosome
Accession NZ_CP098149
Organism Klebsiella pneumoniae strain Z0117KP0019

Toxin (Protein)


Gene name KacT Uniprot ID A0A060VJ83
Locus tag NBY46_RS22745 Protein ID WP_004178461.1
Coordinates 4672032..4672565 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag NBY46_RS22750 Protein ID WP_002887278.1
Coordinates 4672576..4672842 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY46_RS22740 (4670863) 4670863..4671984 + 1122 WP_004186850.1 cupin domain-containing protein -
NBY46_RS22745 (4672032) 4672032..4672565 - 534 WP_004178461.1 type II toxin-antitoxin system toxin KacT Toxin
NBY46_RS22750 (4672576) 4672576..4672842 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
NBY46_RS22755 (4672945) 4672945..4674378 - 1434 WP_004186848.1 Cu(+)/Ag(+) sensor histidine kinase -
NBY46_RS22760 (4674368) 4674368..4675051 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
NBY46_RS22765 (4675224) 4675224..4676609 + 1386 WP_026005908.1 efflux transporter outer membrane subunit -
NBY46_RS22770 (4676627) 4676627..4676971 + 345 WP_004894569.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19810.65 Da        Isoelectric Point: 5.2614

>T246720 WP_004178461.1 NZ_CP098149:c4672565-4672032 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT246720 WP_002887278.1 NZ_CP098149:c4672842-4672576 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060VJ83

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References