Detailed information of TA system TA024672

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): rlegTA/AbiEii-AbiEi
• Location: 3861172..3862727
• Replicon: chromosome
• Accession: NC_013960
• Organism: Nitrosococcus halophilus Nc 4

Toxin (Protein)

• Gene name: rlegT
• Uniprot ID: -
• Locus tag: NHAL_RS18190
• Protein ID: WP_157862678.1
• Coordinates: 3861172..3861999 (-)
• Length: 276 a.a.

Antitoxin (Protein)

• Gene name: rlegA
• Uniprot ID: D5C2U1
• Locus tag: NHAL_RS18195
• Protein ID: WP_013034615.1
• Coordinates: 3862104..3862727 (-)
• Length: 208 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NHAL_RS18165	3856640..3857201	+	562	Protein_3612	Uma2 family endonuclease	-
NHAL_RS18170	3857204..3857632	-	429	WP_013034611.1	tRNA adenosine(34) deaminase TadA	-
NHAL_RS18175	3857806..3858621	-	816	Protein_3614	transposase	-
NHAL_RS21680	3858827..3859027	-	201	WP_203434338.1	hypothetical protein	-
NHAL_RS18180	3859022..3859375	+	354	WP_203434339.1	methyltransferase domain-containing protein	-
NHAL_RS21330	3859624..3859770	+	147	WP_013034613.1	hypothetical protein	-
NHAL_RS20850	3859873..3860079	-	207	WP_049780690.1	hypothetical protein	-
NHAL_RS18185	3860283..3861188	-	906	WP_049780691.1	hypothetical protein	-
NHAL_RS18190	3861172..3861999	-	828	WP_157862678.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
NHAL_RS18195	3862104..3862727	-	624	WP_013034615.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
NHAL_RS18200	3863480..3863764	+	285	WP_013034616.1	helix-turn-helix domain-containing protein	-
NHAL_RS18205	3864009..3865583	-	1575	WP_013034617.1	glutamine-hydrolyzing GMP synthase	-
NHAL_RS18210	3865585..3867045	-	1461	WP_013034618.1	IMP dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (3-238)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (17-61)

Sequences

Toxin

Protein

• Length: 276 a.a.
• Molecular weight: 30551.82 Da
• Isoelectric Point: 5.0591

>T24672 WP_157862678.1 NC_013960:c3861999-3861172 [Nitrosococcus halophilus Nc 4]
MERFLYRLSKSDHADKFVLKGALMFTVWQAPVMRPTLDIDLLGITDNDVEAIVAVMRDICRQDVETDGLAFDVAGVEGER
IVEDADYAGVRVRFRGTLGTARITMQLDIGFGDVVVPKPEAADYPTILDLPAPRLRGYSRESAVAEKFEAMVKLGVVNSR
VKDFFDIWLLSRRFDFDGRTMAQALTETFVTRDTTIPAEPVALTGDFGNDAGRQDQWRGFIRRSRLQNVPSSFAEIVEAV
AVFLGPVTKALAAGERFQGSWKAPGPWRGHYAGNT

Nucleotide

• Length: 828 bp

>T24672 NC_013960:c3861999-3861172 [Nitrosococcus halophilus Nc 4]
ATGGAGCGCTTTCTTTATCGGCTGTCGAAGTCGGATCATGCGGACAAGTTCGTCCTCAAGGGGGCATTGATGTTTACCGT
CTGGCAGGCGCCGGTCATGCGTCCCACCCTGGATATCGACCTACTCGGGATCACCGACAACGACGTCGAGGCTATCGTTG
CGGTCATGAGAGATATCTGCCGCCAAGACGTCGAGACCGACGGGCTGGCTTTCGATGTGGCCGGGGTCGAGGGGGAGCGC
ATCGTCGAGGACGCGGACTACGCCGGCGTTCGCGTGCGGTTTCGGGGAACGCTGGGAACGGCCCGCATCACCATGCAACT
GGACATCGGCTTCGGTGATGTCGTTGTGCCGAAACCCGAAGCGGCGGACTATCCCACGATCCTGGACCTTCCCGCCCCTC
GTCTGAGGGGCTACAGCCGCGAGAGTGCCGTCGCCGAGAAGTTCGAGGCGATGGTCAAGTTGGGCGTGGTCAACAGCCGT
GTGAAGGACTTCTTCGACATCTGGCTGCTGTCCCGGCGGTTCGACTTCGATGGCCGGACAATGGCCCAGGCCCTGACCGA
GACCTTCGTCACCCGGGACACAACGATCCCAGCCGAGCCTGTCGCCTTGACCGGCGACTTCGGCAACGACGCCGGCCGGC
AAGACCAATGGCGGGGGTTCATTCGCAGGAGCCGGTTGCAGAACGTACCAAGCAGCTTCGCTGAAATCGTCGAAGCTGTC
GCCGTTTTCCTCGGCCCAGTCACGAAGGCGCTTGCTGCCGGGGAGCGTTTCCAAGGCTCGTGGAAGGCGCCAGGGCCCTG
GCGTGGTCATTATGCCGGCAACACGTAA

Antitoxin

Protein

• Length: 208 a.a.
• Molecular weight: 23026.89 Da
• Isoelectric Point: 8.6053

>AT24672 WP_013034615.1 NC_013960:c3862727-3862104 [Nitrosococcus halophilus Nc 4]
MTQETTANKGSIDAAIHLFSCHGGVLCTRDALRLGIHPRTLYAMRDAGLLERLSRGLYRLADLPPLGNPDLVAVALKVPG
GVICLISALDYHELTTQIPHEVYLALPRGAEPPRLEHPPLRVFWVGGKAFTEGVETHEVDGVPVRIYGAEKTLADSFKYR
NKIGLDTAIEALRRYVRCGRTRIDMLMAYARICRVEKVIRPYLEALL

Nucleotide

• Length: 624 bp

>AT24672 NC_013960:c3862727-3862104 [Nitrosococcus halophilus Nc 4]
ATGACCCAGGAAACAACCGCCAACAAGGGTTCCATCGACGCGGCGATACACCTGTTCAGCTGCCACGGTGGCGTGCTGTG
CACCCGCGACGCCCTGCGCCTCGGCATCCATCCCAGGACGCTGTACGCGATGCGGGATGCAGGGCTGCTCGAGCGCCTCA
GCCGCGGTCTGTACCGGCTCGCCGATCTGCCGCCCCTGGGCAATCCTGACCTGGTGGCGGTCGCCCTGAAGGTGCCGGGC
GGCGTTATCTGTCTGATCTCGGCGCTGGACTATCACGAGCTCACCACCCAGATCCCCCACGAGGTTTACCTGGCGCTGCC
GCGCGGCGCCGAGCCCCCGCGCCTGGAGCATCCGCCGCTGCGGGTCTTCTGGGTTGGCGGCAAGGCCTTCACCGAGGGCG
TGGAGACCCACGAGGTGGATGGCGTGCCCGTGCGCATCTATGGGGCGGAAAAGACCCTGGCCGACAGCTTCAAGTACCGC
AACAAGATCGGGCTGGACACCGCCATCGAAGCGCTGAGACGCTACGTGCGCTGCGGGCGCACCCGGATCGACATGCTCAT
GGCCTATGCGCGCATCTGCCGGGTGGAAAAGGTGATCCGGCCCTACCTGGAGGCACTGCTGTGA

Structures

Antitoxin

• AlphaFold DB: D5C2U1