Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2679160..2680748 Replicon chromosome
Accession NZ_CP098149
Organism Klebsiella pneumoniae strain Z0117KP0019

Toxin (Protein)


Gene name hipA Uniprot ID A0A9J6RYF8
Locus tag NBY46_RS13105 Protein ID WP_004892016.1
Coordinates 2679160..2680482 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NBY46_RS13110 Protein ID WP_004176198.1
Coordinates 2680482..2680748 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY46_RS13090 (2674216) 2674216..2676717 + 2502 WP_032435337.1 fimbria/pilus outer membrane usher protein -
NBY46_RS13095 (2676705) 2676705..2677709 + 1005 WP_032435338.1 fimbrial protein -
NBY46_RS13100 (2677851) 2677851..2679143 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
NBY46_RS13105 (2679160) 2679160..2680482 - 1323 WP_004892016.1 type II toxin-antitoxin system HipA family toxin Toxin
NBY46_RS13110 (2680482) 2680482..2680748 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NBY46_RS13115 (2681135) 2681135..2681461 - 327 WP_004184023.1 hydroxyisourate hydrolase -
NBY46_RS13120 (2681458) 2681458..2681958 - 501 WP_032435339.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
NBY46_RS13125 (2681936) 2681936..2683315 - 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
NBY46_RS13130 (2683661) 2683661..2684815 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
NBY46_RS13135 (2684796) 2684796..2685719 - 924 WP_008804925.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49141.44 Da        Isoelectric Point: 7.5357

>T246718 WP_004892016.1 NZ_CP098149:c2680482-2679160 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT246718 WP_004176198.1 NZ_CP098149:c2680748-2680482 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References