Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 828857..829514 Replicon chromosome
Accession NZ_CP098149
Organism Klebsiella pneumoniae strain Z0117KP0019

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag NBY46_RS04110 Protein ID WP_002916310.1
Coordinates 829104..829514 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag NBY46_RS04105 Protein ID WP_002916312.1
Coordinates 828857..829123 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY46_RS04080 (824065) 824065..825498 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
NBY46_RS04085 (825617) 825617..826345 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
NBY46_RS04090 (826395) 826395..826706 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
NBY46_RS04095 (826870) 826870..827529 + 660 WP_004174454.1 hemolysin III family protein -
NBY46_RS04100 (827628) 827628..828611 - 984 WP_023286864.1 tRNA-modifying protein YgfZ -
NBY46_RS04105 (828857) 828857..829123 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
NBY46_RS04110 (829104) 829104..829514 + 411 WP_002916310.1 protein YgfX Toxin
NBY46_RS04115 (829521) 829521..830042 - 522 WP_002916308.1 flavodoxin FldB -
NBY46_RS04120 (830143) 830143..831039 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
NBY46_RS04125 (831062) 831062..831775 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NBY46_RS04130 (831781) 831781..833514 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T246712 WP_002916310.1 NZ_CP098149:829104-829514 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT246712 WP_002916312.1 NZ_CP098149:828857-829123 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References