Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/ElaA-DUF1778
Location 162082..162833 Replicon plasmid pZ0117KP0020-2
Accession NZ_CP098147
Organism Klebsiella pneumoniae strain Z0117KP0020

Toxin (Protein)


Gene name ataT Uniprot ID H6U1U8
Locus tag NBY48_RS27625 Protein ID WP_014386536.1
Coordinates 162082..162564 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A071LPN3
Locus tag NBY48_RS27630 Protein ID WP_004902250.1
Coordinates 162555..162833 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY48_RS27605 (NBY48_27600) 158481..159128 - 648 WP_014386537.1 EcsC family protein -
NBY48_RS27610 (NBY48_27605) 159155..159910 - 756 WP_004902235.1 DUF2971 domain-containing protein -
NBY48_RS27615 (NBY48_27610) 160011..160403 - 393 WP_032442757.1 hypothetical protein -
NBY48_RS27620 (NBY48_27615) 160508..161047 - 540 WP_004902239.1 hypothetical protein -
NBY48_RS27625 (NBY48_27620) 162082..162564 - 483 WP_014386536.1 GNAT family N-acetyltransferase Toxin
NBY48_RS27630 (NBY48_27625) 162555..162833 - 279 WP_004902250.1 DUF1778 domain-containing protein Antitoxin
NBY48_RS27635 (NBY48_27630) 162952..163164 - 213 WP_004902255.1 hypothetical protein -
NBY48_RS27640 (NBY48_27635) 163272..163613 - 342 WP_004902257.1 hypothetical protein -
NBY48_RS27645 (NBY48_27640) 164443..164901 - 459 WP_014386535.1 hypothetical protein -
NBY48_RS27650 (NBY48_27645) 165554..166009 - 456 WP_001166628.1 Hg(II)-responsive transcriptional regulator -
NBY48_RS27655 (NBY48_27650) 166081..166446 + 366 WP_001294656.1 mercuric ion transporter MerT -
NBY48_RS27660 (NBY48_27655) 166462..166737 + 276 WP_000732275.1 mercury resistance system periplasmic binding protein MerP -
NBY48_RS27665 (NBY48_27660) 166765..167190 + 426 WP_000522996.1 organomercurial transporter MerC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid tet(B) / aph(3')-Ia / blaTEM-1B / aac(3)-IId / dfrA12 / aadA2 / qacE / sul1 / blaCTX-M-9 / aadA5 / dfrA1 - 1..285767 285767


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(10-86)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17662.45 Da        Isoelectric Point: 8.9130

>T246709 WP_014386536.1 NZ_CP098147:c162564-162082 [Klebsiella pneumoniae]
MGMRAPESLTAEHNIAEFCCQEPALNEWLKKKALRNHSTGISRVYVVCAENTNRVIGYYCLSSGSVHRNTVPGAYRRNAP
DVIPVIVLGRLAIDQAWAGNGLGAALLKDAIYRTQNIAFQVGVRALAVHALNEEVKCFYTRFGFEPSIVNTLTLLFPIKV

Download         Length: 483 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10704.23 Da        Isoelectric Point: 4.5271

>AT246709 WP_004902250.1 NZ_CP098147:c162833-162555 [Klebsiella pneumoniae]
MKPDVREAPINIRAKTSQRDLIDMAASLVSKSRTDFMLEVACREAQDILLDQRLFLLNDNQFEAFIEELDAPITPERQAR
IDNLMNRKSPWE

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MBI1

Antitoxin

Source ID Structure
AlphaFold DB A0A071LPN3

References