Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-TIGR02293 |
| Location | 79877..80787 | Replicon | plasmid pZ0117KP0020-2 |
| Accession | NZ_CP098147 | ||
| Organism | Klebsiella pneumoniae strain Z0117KP0020 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A663AYG0 |
| Locus tag | NBY48_RS27230 | Protein ID | WP_004026354.1 |
| Coordinates | 80317..80787 (+) | Length | 157 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A2J4RLY9 |
| Locus tag | NBY48_RS27225 | Protein ID | WP_004181895.1 |
| Coordinates | 79877..80320 (+) | Length | 148 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NBY48_RS27210 (NBY48_27205) | 76510..77997 | + | 1488 | WP_004178082.1 | group II intron reverse transcriptase/maturase | - |
| NBY48_RS27215 (NBY48_27210) | 78083..78505 | + | 423 | WP_004181893.1 | translesion error-prone DNA polymerase V autoproteolytic subunit | - |
| NBY48_RS27220 (NBY48_27215) | 78505..79776 | + | 1272 | WP_004181894.1 | translesion error-prone DNA polymerase V subunit UmuC | - |
| NBY48_RS27225 (NBY48_27220) | 79877..80320 | + | 444 | WP_004181895.1 | DUF2384 domain-containing protein | Antitoxin |
| NBY48_RS27230 (NBY48_27225) | 80317..80787 | + | 471 | WP_004026354.1 | RES family NAD+ phosphorylase | Toxin |
| NBY48_RS27235 (NBY48_27230) | 80897..81157 | - | 261 | WP_004026352.1 | hypothetical protein | - |
| NBY48_RS27240 (NBY48_27235) | 81881..82039 | + | 159 | WP_004181898.1 | type I toxin-antitoxin system Hok family toxin | - |
| NBY48_RS27245 (NBY48_27240) | 82642..83616 | + | 975 | WP_014386572.1 | hypothetical protein | - |
| NBY48_RS27250 (NBY48_27245) | 83814..84191 | - | 378 | WP_004181901.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | tet(B) / aph(3')-Ia / blaTEM-1B / aac(3)-IId / dfrA12 / aadA2 / qacE / sul1 / blaCTX-M-9 / aadA5 / dfrA1 | - | 1..285767 | 285767 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17515.79 Da Isoelectric Point: 4.6155
>T246708 WP_004026354.1 NZ_CP098147:80317-80787 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
Antitoxin
Download Length: 148 a.a. Molecular weight: 16536.87 Da Isoelectric Point: 10.3013
>AT246708 WP_004181895.1 NZ_CP098147:79877-80320 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A663AYG0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2J4RLY9 |