Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4510765..4511422 Replicon chromosome
Accession NZ_CP098145
Organism Klebsiella pneumoniae strain Z0117KP0020

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag NBY48_RS21830 Protein ID WP_002916310.1
Coordinates 4510765..4511175 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag NBY48_RS21835 Protein ID WP_002916312.1
Coordinates 4511156..4511422 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY48_RS21810 (4506765) 4506765..4508498 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
NBY48_RS21815 (4508504) 4508504..4509217 - 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NBY48_RS21820 (4509240) 4509240..4510136 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
NBY48_RS21825 (4510237) 4510237..4510758 + 522 WP_002916308.1 flavodoxin FldB -
NBY48_RS21830 (4510765) 4510765..4511175 - 411 WP_002916310.1 protein YgfX Toxin
NBY48_RS21835 (4511156) 4511156..4511422 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
NBY48_RS21840 (4511668) 4511668..4512651 + 984 WP_023286864.1 tRNA-modifying protein YgfZ -
NBY48_RS21845 (4512750) 4512750..4513409 - 660 WP_004174454.1 hemolysin III family protein -
NBY48_RS21850 (4513573) 4513573..4513884 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
NBY48_RS21855 (4513934) 4513934..4514662 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
NBY48_RS21860 (4514781) 4514781..4516214 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T246704 WP_002916310.1 NZ_CP098145:c4511175-4510765 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT246704 WP_002916312.1 NZ_CP098145:c4511422-4511156 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References