Detailed information of TA system TA024670

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 3361703..3362352
• Replicon: chromosome
• Accession: NC_013960
• Organism: Nitrosococcus halophilus Nc 4

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: NHAL_RS15865
• Protein ID: WP_041355866.1
• Coordinates: 3361939..3362352 (+)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: D5C066
• Locus tag: NHAL_RS15860
• Protein ID: WP_013034162.1
• Coordinates: 3361703..3361936 (+)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NHAL_RS15830	3357245..3357994	+	750	WP_013034155.1	PEP-CTERM/exosortase system-associated acyltransferase	-
NHAL_RS15835	3358328..3359212	+	885	WP_013034156.1	PEP-CTERM/exosortase system-associated acyltransferase	-
NHAL_RS21275	3359773..3359931	-	159	WP_013034157.1	hypothetical protein	-
NHAL_RS21670	3359915..3360055	-	141	WP_013034158.1	hypothetical protein	-
NHAL_RS15845	3360288..3360497	+	210	WP_013034159.1	hypothetical protein	-
NHAL_RS15850	3360497..3360775	+	279	WP_013034160.1	type II toxin-antitoxin system RelE/ParE family toxin	-
NHAL_RS21675	3360772..3360891	-	120	WP_203434412.1	DUF433 domain-containing protein	-
NHAL_RS15855	3361103..3361504	-	402	WP_013034161.1	hypothetical protein	-
NHAL_RS15860	3361703..3361936	+	234	WP_013034162.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
NHAL_RS15865	3361939..3362352	+	414	WP_041355866.1	type II toxin-antitoxin system VapC family toxin	Toxin
NHAL_RS15870	3362594..3363949	-	1356	WP_013034165.1	PEP-CTERM-box response regulator transcription factor	-
NHAL_RS15875	3363946..3366024	-	2079	WP_013034166.1	PEP-CTERM system histidine kinase PrsK	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (6-118)

Antitoxin

• SpoVT-AbrB domain (10-54)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 14798.27 Da
• Isoelectric Point: 5.1719

>T24670 WP_041355866.1 NC_013960:3361939-3362352 [Nitrosococcus halophilus Nc 4]
MAEYRYLLDTNILSSLIKKPSGTVASRIATVGENTICTSIIVACELRYGAAKKASPLLSQKINALLSAIDVLPLDNEVDR
SYGDLRAMLEKVGTPIGANDYLIAAQALCLELVLVTGNMGEFSRVPDLKVENWLVAK

Nucleotide

• Length: 414 bp

>T24670 NC_013960:3361939-3362352 [Nitrosococcus halophilus Nc 4]
ATGGCCGAATATCGCTATCTACTCGATACCAACATTCTGTCCAGCCTCATCAAAAAACCCTCTGGCACGGTCGCAAGTCG
GATTGCCACAGTGGGAGAAAATACCATTTGTACCAGCATTATCGTCGCTTGCGAACTCCGCTATGGTGCCGCGAAAAAAG
CTTCACCCCTCCTCTCTCAGAAGATTAATGCGTTGCTCTCGGCAATCGATGTACTGCCCTTGGATAATGAGGTAGACAGG
TCCTATGGCGATTTGCGGGCAATGCTAGAAAAAGTCGGCACGCCGATTGGAGCCAATGATTACCTAATTGCAGCGCAGGC
CCTTTGCTTGGAACTGGTATTGGTAACCGGTAACATGGGAGAGTTTTCTAGAGTGCCTGATCTCAAAGTGGAAAACTGGC
TAGTGGCCAAGTGA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 9064.39 Da
• Isoelectric Point: 5.1585

>AT24670 WP_013034162.1 NC_013960:3361703-3361936 [Nitrosococcus halophilus Nc 4]
MQAERHVRLFRNGRNQALRIPREFELPGNEAIIRKEGDRLIVEPVQRRSLLALLATWEPLEEDFPEIKDLHPDPVDL

Nucleotide

• Length: 234 bp

>AT24670 NC_013960:3361703-3361936 [Nitrosococcus halophilus Nc 4]
ATGCAAGCAGAACGCCATGTCCGTTTATTCAGAAACGGCCGCAATCAGGCGCTACGAATTCCCCGCGAATTCGAGCTGCC
CGGAAATGAGGCCATTATCCGTAAAGAAGGTGATCGACTAATCGTCGAACCGGTCCAGCGTCGCTCATTACTGGCGTTGC
TCGCCACATGGGAGCCGCTGGAAGAGGACTTCCCGGAAATCAAAGACTTGCATCCTGATCCTGTTGATCTTTAA

Structures

Antitoxin

• AlphaFold DB: D5C066