Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2657827..2659415 Replicon chromosome
Accession NZ_CP098145
Organism Klebsiella pneumoniae strain Z0117KP0020

Toxin (Protein)


Gene name hipA Uniprot ID A0A9J6RYF8
Locus tag NBY48_RS12825 Protein ID WP_004892016.1
Coordinates 2658093..2659415 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NBY48_RS12820 Protein ID WP_004176198.1
Coordinates 2657827..2658093 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY48_RS12795 (2652856) 2652856..2653779 + 924 WP_008804925.1 LysR family hpxDE operon transcriptional regulator HpxR -
NBY48_RS12800 (2653760) 2653760..2654914 - 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
NBY48_RS12805 (2655260) 2655260..2656639 + 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
NBY48_RS12810 (2656617) 2656617..2657117 + 501 WP_032435339.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
NBY48_RS12815 (2657114) 2657114..2657440 + 327 WP_004184023.1 hydroxyisourate hydrolase -
NBY48_RS12820 (2657827) 2657827..2658093 + 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NBY48_RS12825 (2658093) 2658093..2659415 + 1323 WP_004892016.1 type II toxin-antitoxin system HipA family toxin Toxin
NBY48_RS12830 (2659432) 2659432..2660724 - 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
NBY48_RS12835 (2660866) 2660866..2661870 - 1005 WP_032435338.1 fimbrial protein -
NBY48_RS12840 (2661858) 2661858..2664359 - 2502 WP_032435337.1 fimbria/pilus outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49141.44 Da        Isoelectric Point: 7.5357

>T246698 WP_004892016.1 NZ_CP098145:2658093-2659415 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT246698 WP_004176198.1 NZ_CP098145:2657827-2658093 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References