Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 529211..529727 Replicon chromosome
Accession NZ_CP098145
Organism Klebsiella pneumoniae strain Z0117KP0020

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag NBY48_RS02515 Protein ID WP_004178374.1
Coordinates 529443..529727 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A919M0P8
Locus tag NBY48_RS02510 Protein ID WP_032434351.1
Coordinates 529211..529453 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY48_RS02495 (525240) 525240..525980 + 741 WP_002886899.1 KDGP aldolase family protein -
NBY48_RS02500 (526046) 526046..527200 + 1155 WP_002886900.1 lactonase family protein -
NBY48_RS02505 (527223) 527223..529133 + 1911 WP_004152270.1 PRD domain-containing protein -
NBY48_RS02510 (529211) 529211..529453 + 243 WP_032434351.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NBY48_RS02515 (529443) 529443..529727 + 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NBY48_RS02520 (529731) 529731..530195 - 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NBY48_RS02525 (530437) 530437..532575 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
NBY48_RS02530 (532932) 532932..533675 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
NBY48_RS02535 (533678) 533678..533851 - 174 WP_032414379.1 hypothetical protein -
NBY48_RS02540 (533981) 533981..534244 + 264 WP_014908078.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-68)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T246694 WP_004178374.1 NZ_CP098145:529443-529727 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9003.47 Da        Isoelectric Point: 6.3340

>AT246694 WP_032434351.1 NZ_CP098145:529211-529453 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGGKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure

References